Airway epithelial dysfunction
Status: proposedEvidence level: proposed framework, abstract only
Dysfunction of the airway lining (epithelium) is named in the review abstract among the pathways involved in CLAD. Proposed framework, abstract only.
As of . Primary source: Burman et al. 2026, J Heart Lung Transplant (DOI; abstract only was read).
Summary
The abstract of the review by Burman and colleagues names epithelial dysfunction, that is, dysfunction of the airway lining, among the pathways involved in CLAD. The abstract does not state the strength of the evidence for this pathway, and the full text was not read. Only the abstract of the source review was read; the full text was not read. Status: proposed framework.
Sources and links
Related
Links from this record
- described in (abstract only): CLAD: translating basic science to clinical practice
- part of proposed framework: Molecular endotypes of CLAD (proposed framework)
Linked from (derived)
- pathway named in abstract: Molecular endotypes of CLAD (proposed framework)
- supports: Epithelial cell death markers in bronchoalveolar lavage correlate with chronic lung allograft dysfunction subtypes and survival in lung transplant recipients-a single-center retrospective cohort study
- supports: Pulmonary epithelial markers in phenotypes of chronic lung allograft dysfunction
- supports: An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants
- supports: Spectrum of chronic lung allograft dysfunction pathology in human lung transplantation.
- describes: Detailed cellular and spatial characterization of chronic lung allograft dysfunction using imaging mass cytometry
- supports: Reduced lung fluid club cell secretory protein informs chronic lung allograft dysfunction risk
- supports: Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study
Known gaps in this record
- full text of the source review not read, so the evidence, citations and level of agreement for this item are missing
- funding and conflicts of interest of the source review not read
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.