Detailed cellular and spatial characterization of chronic lung allograft dysfunction using imaging mass cytometry
Evidence level: human tissue, very small sample; abstract-only
Imaging mass cytometry of four BOS, four RAS and four control lungs found fewer club cells in CLAD and a Ki67-high basal cell population mainly in RAS.
As of . Primary source: Publisher record via DOI.
Summary
The authors applied imaging mass cytometry with 35 metal-tagged antibodies to 4 BOS, 4 RAS and 4 control lung samples and identified 50 immune and non-immune cell clusters. According to the abstract, CLAD lungs had significantly fewer club cells, a Ki67-high basal cell population was mostly present in RAS and near memory T cells, memory CD8+ T cells were more frequent in CLAD lungs, and regulatory T cells were more prominent in RAS. The sample is very small and the work is descriptive.
Details
- doi
- 10.1016/j.healun.2024.09.023
- pmid
- 39368678
- authors
- Renaud-Picard B, Moshkelgosha S, Berra G, Cheung M, Hwang D, Hedley D, Juvet S, Martinu T
- journal
- The Journal of Heart and Lung Transplantation
- year
- 2025
- volume
- 44
- issue
- 1
- pages
- 118-124
Sources and links
- Publisher record via DOI (primary)
- PubMed 39368678
Related
Links from this record
- compares: Bronchiolitis obliterans syndrome (BOS)
- compares: Restrictive allograft syndrome (RAS)
- describes: Airway epithelial dysfunction
- describes: Cytotoxic and senescent T cells
- authors affiliated with: Toronto Lung Transplant Program (University Health Network)
- coauthor: Tereza Martinu
- coauthor: Stephen Juvet
Linked from (derived)
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- which explant or biopsy source was used (not stated in abstract)
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.