Pulmonary epithelial markers in phenotypes of chronic lung allograft dysfunction

Summary

This retrospective study measured club cell secretory protein, surfactant protein-D, mucins and epithelial cell death markers in lavage within 6 months after CLAD onset in first bilateral recipients transplanted 2010 to 2015. It included 54 CLAD patients (27 BOS, 11 RAS, 7 mixed, 9 others with RAS-like opacities) and 23 CLAD-free controls. Median levels were significantly higher in CLAD for M30 (124.5 vs 88.7 U/L), MUC1 and MUC16, and M30 was higher in RAS-related phenotypes than BOS (160.9 vs 114.6 U/L). Higher M30 and MUC5B were associated with decreased allograft survival after CLAD onset independent of phenotype. The authors suggest epithelial death and abnormal mucin expression may be involved in pathogenesis. Associations do not show cause.

Details

doi

10.1016/j.healun.2023.03.009

pmid

36963446

authors

Levy L, Moshkelgosha S, Huszti E, Hunter S, Renaud-Picard B, Berra G, Kawashima M, Fernandez-Castillo J, Fuchs E, Dianti M, Ghany R, Keshavjee S, Singer LG, Tikkanen J, Martinu T

journal

The Journal of Heart and Lung Transplantation

year

2023

volume

42

issue

8

pages

1152-1160

Sources and links

• Publisher record via DOI (primary)
• PubMed 36963446

Related

Links from this record

• evidence for: Epithelial injury markers
• compares: Bronchiolitis obliterans syndrome (BOS)
• compares: Restrictive allograft syndrome (RAS)
• compares: Mixed phenotype
• supports: Airway epithelial dysfunction
• authors affiliated with: Toronto Lung Transplant Program (University Health Network)
• coauthor: Lianne Singer
• coauthor: Shaf Keshavjee
• coauthor: Tereza Martinu

Linked from (derived)

• author: Lianne Singer
• author: Rasheed Ghany
• author: Shaf Keshavjee
• author: Tereza Martinu

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• external validation