Epithelial cell death markers in bronchoalveolar lavage correlate with chronic lung allograft dysfunction subtypes and survival in lung transplant recipients-a single-center retrospective cohort study

Summary

The study measured M30 and M65, cytokeratin-18 fragments released during epithelial cell apoptosis and total cell death, in bronchoalveolar lavage (BAL) fluid. Samples came from 26 patients with established CLAD (10 with RAS and 16 with BOS) and 19 long-term CLAD-free controls, with infection and acute rejection excluded. The abstract reports that M65 was significantly higher in RAS than in BOS and controls and correlated with worse survival after CLAD onset. The authors conclude that lung epithelial cell death is enhanced in RAS and that BAL M65 may help differentiate CLAD subtypes and serve as a prognostic marker. The cohort is small and single-centre, and the centre is not named in the abstract.

Details

doi

10.1111/tri.13444

pmid

31002407

authors

Levy L, Tigert A, Huszti E, Saito T, Mitsakakis N, Moshkelgosha S, Joe B, Boonstra KM, Tikkanen JM, Keshavjee S, Juvet SC, Martinu T

journal

Transplant International

year

2019

volume

32

issue

9

pages

965-973

Sources and links

• Publisher record via DOI (primary)
• PubMed 31002407

Related

Links from this record

• compares: Restrictive allograft syndrome (RAS)
• compares: Bronchiolitis obliterans syndrome (BOS)
• reports: Epithelial injury markers
• supports: Airway epithelial dysfunction
• coauthor: Tereza Martinu
• coauthor: Stephen Juvet

Linked from (derived)

• supports: Bronchoalveolar lavage: cell counts, microbiology and protein markers

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• author affiliations
• centre or centres not stated in the abstract