Reduced lung fluid club cell secretory protein informs chronic lung allograft dysfunction risk
Evidence level: prospective observational validation cohort; abstract-only
A validation study in 353 lung recipients that did not confirm the earlier lavage CCSP threshold on its own, but found the association with CLAD risk in the combined cohorts.
As of . Primary source: Publisher record via DOI.
Summary
This study tried to validate an earlier finding that low club cell secretory protein (CCSP) in lavage fluid early after transplant identifies a higher risk of CLAD. It measured CCSP in 1,481 samples from 353 patients in an independent validation cohort. In that cohort alone the earlier threshold was not significantly associated with CLAD (hazard ratio 1.41, p = 0.208). In the combined discovery and validation cohorts, a threshold of 8.63 ng per microgram had the largest hazard ratio, and resampling showed the association was reproducible. Biopsies from samples with reduced CCSP showed a pro-inflammatory gene expression profile in a subset. The authors conclude that early reductions in lavage CCSP identify recipients at higher CLAD risk and may reflect heightened inflammation. The threshold was re-derived in the combined cohort, so it is not independently confirmed by this abstract.
Details
- doi
- 10.1183/13993003.00182-2025
- pmid
- 41309269
- authors
- Rim JG, Weber JM, Neely ML, O'Grady N, Kelly FL, Myers RA, Nagler A, McArthur P, Frankel CW, Belperio JA, Budev M, Hartwig MG, Martinu T, Reynolds JM, Shah PD, Singer LG, Snyder LD, Weigt SS, Palmer SM, Todd JL
- journal
- European Respiratory Journal
- year
- 2026
- volume
- 67
- issue
- 4
- pages
- 2500182
- publishedOnline
- 2025-11-27
Sources and links
- Publisher record via DOI (primary)
- PubMed 41309269
Related
Links from this record
- supports: Epithelial injury markers
- supports: Airway epithelial dysfunction
- coauthor: Tereza Martinu
Linked from (derived)
- author affiliation matches this institution (PubMed): Cleveland Clinic Lung Transplant Program
- author affiliation matches this institution (PubMed): Duke Lung Transplant Program
- author affiliation matches this institution (PubMed): Johns Hopkins Lung Transplant Program
- author affiliation matches this institution (PubMed): UCLA Lung Transplant Program
- evidence: Biomarker findings are hard to validate and generalise across centres
- evidence: CLAD is recognised late and no biomarker is validated for early warning
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- author affiliations
- centre or centres not stated in the abstract
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.