Cytotoxic and senescent T cells
Status: proposedEvidence level: proposed framework, abstract only
Cytotoxic T cells and senescent T cells are named in the review abstract among the pathways involved in CLAD. Proposed framework, abstract only.
As of . Primary source: Burman et al. 2026, J Heart Lung Transplant (DOI; abstract only was read).
Summary
The abstract of the review by Burman and colleagues names cytotoxic T cells and senescent T cells among the pathways involved in CLAD. Senescent cells are aged cells that have stopped dividing. The abstract does not state the strength of the evidence for this pathway, and the full text was not read. Only the abstract of the source review was read; the full text was not read. Status: proposed framework.
Sources and links
Related
Links from this record
- described in (abstract only): CLAD: translating basic science to clinical practice
- part of proposed framework: Molecular endotypes of CLAD (proposed framework)
Linked from (derived)
- pathway named in abstract: Molecular endotypes of CLAD (proposed framework)
- describes: The CD8+ T cell content of transbronchial biopsies from patients with a first episode of clinically stable grade A1 cellular rejection is associated with future chronic lung allograft dysfunction
- relates to: Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction
- describes: Persistent and progressive acute lung allograft dysfunction is linked to cell compositional and transcriptional changes in small airways
- related to: Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression
- supports: An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants
- supports: Reprogramming alveolar macrophage responses to TGF-β reveals CCR2+ monocyte activity that promotes bronchiolitis obliterans syndrome
- supports: Shared roles of immune and stromal cells in the pathogenesis of human bronchiolitis obliterans syndrome
- describes: Emergence of a senescent and inflammatory pulmonary CD4+ T cell population prior to lung allograft failure
- describes: Detailed cellular and spatial characterization of chronic lung allograft dysfunction using imaging mass cytometry
- related to: Single-cell dissection of chronic lung allograft dysfunction reveals convergent and distinct fibrotic mechanisms
Known gaps in this record
- full text of the source review not read, so the evidence, citations and level of agreement for this item are missing
- funding and conflicts of interest of the source review not read
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.