Cytomegalovirus and respiratory infection
Evidence level: abstract-only observational studies; association, not causation
CMV pneumonitis and community-acquired respiratory virus infection are reported to be associated with CLAD or BOS in cohort abstracts.
As of . Primary source: Snyder et al. 2010 (DOI).
Summary
According to the abstracts read, treated cytomegalovirus pneumonitis within the first 6 months was associated with an increased risk of BOS (hazard ratio 2.19) and death in a cohort of 231 recipients; in a Barcelona cohort of 98 recipients, community-acquired respiratory virus lower respiratory tract infection (hazard ratio 3.00) and CMV pneumonitis (hazard ratio 3.76) were independent risk factors for CLAD; a KU Leuven case-control study reports a higher incidence of infections, including CMV and SARS-CoV-2, in patients with RAS than in matched controls; and a cohort abstract (Verleden 2013) reports infection as more frequent before BOS or RAS. All are observational and show association; this record gives no advice on prevention or treatment.
Sources and links
Related
Links from this record
- supports: Cytomegalovirus Pneumonitis Is a Risk for Bronchiolitis Obliterans Syndrome in Lung Transplantation.
- supports: Community-acquired Respiratory Viruses Are a Risk Factor for Chronic Lung Allograft Dysfunction.
- supports: Clinical predictors for restrictive allograft syndrome: A nested case-control study.
- supports: Bronchiolitis obliterans syndrome and restrictive allograft syndrome: do risk factors differ?
- reported association: Bronchiolitis obliterans syndrome (BOS)
- reported association: Restrictive allograft syndrome (RAS)
Linked from (derived)
Known gaps in this record
- studies reporting no association (for example early CMV work) were not read
- full text of all sources
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.