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Paper

Community-acquired Respiratory Viruses Are a Risk Factor for Chronic Lung Allograft Dysfunction.

Evidence level: prospective single-centre cohort (98 recipients); abstract-only

A prospective Barcelona cohort of 98 lung transplant recipients reporting that lower respiratory tract infection with community-acquired respiratory viruses was an independent risk factor for CLAD.

As of . Primary source: Publisher record via DOI.

Summary

According to the abstract, 98 consecutive adults transplanted at the Hospital Universitari Vall d'Hebron in Barcelona between 2009 and 2014 had nasopharyngeal swabs analysed by multiplex PCR, and 38 (38.8 percent) developed CLAD after a median of 20.4 months. In time-dependent Cox models, community-acquired respiratory virus lower respiratory tract infection (hazard ratio 3.00, 95 percent confidence interval 1.52 to 5.91), acute rejection (hazard ratio 2.97, 1.51 to 5.83) and cytomegalovirus pneumonitis (hazard ratio 3.76, 1.23 to 11.49) were independent risk factors for CLAD. The abstract states that recipients with such viruses in the lower respiratory tract are at increased risk of CLAD. The design is a prospective single-centre cohort and shows association.

Details

doi
10.1093/cid/ciy1047
pmid
30561555
authors
Peghin M, Los-Arcos I, Hirsch HH, Codina G, Monforte V, Bravo C, Berastegui C, Jauregui A, Romero L, Cabral E, Ferrer R, Sacanell J, Román A, Len O, Gavaldà J
journal
Clinical Infectious Diseases
year
2019
volume
69
issue
7
pages
1192-1197
publishedOnline
2018-12-17

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Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.