Bronchiolitis obliterans syndrome and restrictive allograft syndrome: do risk factors differ?

Summary

This retrospective analysis of a lung transplantation cohort of 380 patients identified 103 with chronic rejection, of whom 79 had BOS and 24 had RAS. The abstract reports that infection, pseudomonal colonisation, acute rejection and lymphocytic bronchiolitis were more frequent in both BOS and RAS than in stable patients, that severe lymphocytic bronchiolitis was more frequent in RAS than in BOS, and that episodes of raised lavage eosinophils were more frequent in RAS. The authors conclude that acute rejection, lymphocytic bronchiolitis, pseudomonas colonisation, infection and lavage eosinophilia and neutrophilia are risk factors for the later development of both RAS and BOS. The study is retrospective and shows association only. The abstract does not name the centre.

Details

doi

10.1097/tp.0b013e318286e076

pmid

23425818

authors

Verleden SE, Ruttens D, Vandermeulen E, Vaneylen A, Dupont LJ, Van Raemdonck DE, Verleden GM, Vanaudenaerde BM, Vos R

journal

Transplantation

year

2013

volume

95

issue

9

pages

1167-1172

Sources and links

• Publisher record via DOI (primary)
• PubMed 23425818

Related

Links from this record

• compares risk factors of: Bronchiolitis obliterans syndrome (BOS)
• compares risk factors of: Restrictive allograft syndrome (RAS)

Linked from (derived)

• supports: Acute cellular rejection
• supports: Airway colonisation: Pseudomonas and fungal infection
• supports: Cytomegalovirus and respiratory infection

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• author affiliations
• centre or centres not stated in the abstract