Triaging donor lungs based on a microaspiration signature that predicts adverse recipient outcome
Evidence level: retrospective single-centre cohort; abstract-only
Bile acid levels in 605 Toronto donor lungs related to donor suitability, performance on ex vivo perfusion and shorter time to CLAD in recipients.
As of . Primary source: Publisher record via DOI.
Summary
Total bile acids were measured in large airway bronchial wash from 605 consecutive lung donors at the Toronto Lung Transplant Program. Levels were highest in lungs deemed unsuitable for transplant, and a cut-off of 1245 nM separated directly declined donor lungs from those suitable for direct transplantation with 91 percent specificity (AUROC 73 percent). High donor bile acids were associated with more primary graft dysfunction, longer time to extubation and shorter time to CLAD. It is a large retrospective single-programme cohort and the associations do not show cause.
Details
- doi
- 10.1016/j.healun.2022.12.024
- pmid
- 36710092
- authors
- Ramendra R, Sage AT, Yeung J, Fernandez-Castillo JC, Cuesta M, Aversa M, Liu M, Cypel M, Keshavjee S, Martinu T
- journal
- The Journal of Heart and Lung Transplantation
- year
- 2023
- volume
- 42
- issue
- 4
- pages
- 456-465
Sources and links
- Publisher record via DOI (primary)
- PubMed 36710092
Related
Links from this record
- describes cohort at: Toronto Lung Transplant Program (University Health Network)
- describes: Aspiration
- studies: Gastro-oesophageal reflux, oesophageal dysmotility and aspiration
- studies: Primary graft dysfunction
- coauthor: Andrew Sage
- coauthor: Shaf Keshavjee
- coauthor: Marcelo Cypel
- coauthor: Tereza Martinu
Linked from (derived)
- author: Andrew Sage
- author: Marcelo Cypel
- author: Shaf Keshavjee
- author: Tereza Martinu
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- external validation of the cut-off
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.