Primary graft dysfunction
Evidence level: abstract-only observational studies; association, not causation
One cohort abstract reports that primary graft dysfunction was associated with a higher risk of BOS, rising with its grade.
As of . Primary source: Daud et al. 2007 (DOI).
Summary
According to the abstract of Daud and colleagues (2007), a retrospective cohort of 334 recipients graded by the ISHLT definition showed that all grades of primary graft dysfunction were associated with an increased risk of BOS stage 1 in univariable analysis (relative risk 1.73, 2.13 and 2.53 for grades 1, 2 and 3 compared with grade 0), and that the association was independent of acute rejection, lymphocytic bronchitis and community-acquired respiratory viral infections. This is a single study from the BOS era; the evidence on CLAD as now defined, and on mechanisms, was not opened for this record.
Sources and links
- Daud et al. 2007 (DOI) (primary)
Related
Links from this record
- supports: Impact of Immediate Primary Lung Allograft Dysfunction on Bronchiolitis Obliterans Syndrome.
- reported association: Bronchiolitis obliterans syndrome (BOS)
Linked from (derived)
Known gaps in this record
- studies on PGD and CLAD under the 2019 definition (candidates found but not read; see MISSING.md)
- phenotype-specific data
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.