Bronchoalveolar lavage cytokine-based risk stratification of clinically-stable lung transplant recipients with undefined rejection: Further insights from a follow-up investigation

Summary

This follow-up study included adult first bilateral lung recipients transplanted 2010 to 2017 who were clinically stable (no 10 percent or greater FEV1 drop) and had inadequate (grade AX) transbronchial biopsies in the first year. Seven proteins (IL6, S100A8, IL10, TNF-receptor-1, IL1 alpha, pentraxin 3 and CXCL10) were measured in lavage by multiplex bead assay. Among 107 patients, with biopsy at a median of 188 days after transplant, CXCL10 was significantly associated with CLAD, while IL6, S100A8, pentraxin 3, TNF-receptor-1 and IL10 were associated with death or retransplant (p below 0.05). The authors suggest such markers may identify patients needing closer monitoring. It is a retrospective association study and does not show cause and effect.

Details

doi

10.1016/j.healun.2024.11.020

pmid

39571635

authors

Levy L, Moshkelgosha S, Huszti E, Wang S, Hunter S, Zhang CYK, Ghany R, Keshavjee S, Singer LG, Tikkanen J, Juvet S, Martinu T

journal

The Journal of Heart and Lung Transplantation

year

2025

volume

44

issue

4

pages

634-642

Sources and links

• Publisher record via DOI (primary)
• PubMed 39571635

Related

Links from this record

• uses: Bronchoalveolar lavage: cell counts, microbiology and protein markers
• relates to: Transbronchial biopsy: histology and transcript-based classifiers
• authors affiliated with: Toronto Lung Transplant Program (University Health Network)
• coauthor: Lianne Singer
• coauthor: Shaf Keshavjee
• coauthor: Tereza Martinu
• coauthor: Stephen Juvet

Linked from (derived)

• author: Lianne Singer
• author: Shaf Keshavjee
• author: Stephen Juvet
• author: Tereza Martinu

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• validation in an independent cohort (not stated in abstract)