Antibodies to K-α 1 Tubulin and Collagen V Are Associated With Chronic Rejection After Lung Transplantation

Summary

The study retrospectively analysed serum from 108 lung transplant recipients for antibodies to the self-antigens K-alpha 1 tubulin and collagen V, before and after antibody-directed therapy (rituximab and/or intravenous immune globulin), and related the results to later BOS. According to the abstract, 72 of the 108 recipients developed antibodies to self-antigens, and these correlated with donor-specific HLA antibodies. Of 54 treated patients with such antibodies, 16 cleared them, and these patients were significantly less likely to develop BOS than those with persistent antibodies. Patients who cleared donor-specific antibodies but kept antibodies to self-antigens were significantly more likely to develop BOS. The authors conclude that antibodies to self-antigens are an important risk factor for BOS. The design is observational, and the abstract does not name the centre.

Details

doi

10.1111/j.1600-6143.2012.04079.x

pmid

22568593

authors

Hachem R, Tiriveedhi V, Patterson G, Aloush A, Trulock E, Mohanakumar T

journal

American Journal of Transplantation

year

2012

volume

12

issue

8

pages

2164-2171

Sources and links

• Publisher record via DOI (primary)
• PubMed 22568593

Related

Links from this record

• supports: Humoral (antibody-mediated) alloimmunity
• supports: Autoantibodies
• discusses: Bronchiolitis obliterans syndrome (BOS)

Linked from (derived)

• author affiliation matches this institution (PubMed): Lung Transplant Program, Washington University in St. Louis and Barnes-Jewish Hospital

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• author affiliations
• centre or centres not stated in the abstract