Humoral (antibody-mediated) alloimmunity
Status: proposedEvidence level: proposed framework, abstract only
Humoral, meaning antibody-mediated, immunity is named in the review abstract among the pathways involved in CLAD. Proposed framework, abstract only.
As of . Primary source: Burman et al. 2026, J Heart Lung Transplant (DOI; abstract only was read).
Summary
The abstract of the review by Burman and colleagues names humoral immunity, that is, antibody-mediated immunity against the graft, among the pathways involved in CLAD. The abstract does not state the strength of the evidence for this pathway, and the full text was not read. Only the abstract of the source review was read; the full text was not read. Status: proposed framework.
Sources and links
Related
Links from this record
- described in (abstract only): CLAD: translating basic science to clinical practice
- part of proposed framework: Molecular endotypes of CLAD (proposed framework)
Linked from (derived)
- pathway named in abstract: Molecular endotypes of CLAD (proposed framework)
- related to: HLA donor-specific antibody and non-HLA antibody testing
- related to: Antibody-mediated rejection and donor-specific antibodies
- supports: Clinical predictors for restrictive allograft syndrome: A nested case-control study.
- supports: Antibodies to K-α 1 Tubulin and Collagen V Are Associated With Chronic Rejection After Lung Transplantation
- supports: Local intragraft humoral immune responses in chronic lung allograft dysfunction.
- supports: De Novo DQ Donor-Specific Antibodies Are Associated with Chronic Lung Allograft Dysfunction after Lung Transplantation
- supports: Donor-specific and -nonspecific HLA antibodies and outcome post lung transplantation
- supports: Humoral immunity to lung antigens early post-transplant confers risk for chronic lung allograft dysfunction.
- supports: Chronic lung allograft dysfunction is associated with an increased number of non-HLA antibodies
- affects: Pulmonary antibody-mediated rejection has dismal outcomes and no established treatment platform
Known gaps in this record
- full text of the source review not read, so the evidence, citations and level of agreement for this item are missing
- funding and conflicts of interest of the source review not read
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.