Undefined phenotype

Summary

The 2026 ScanCLAD study describes the undefined category as presentations meeting CLAD criteria but not fitting the BOS, RAS or mixed definitions, and it adds a separate unclassifiable category for presentations that the current consensus criteria do not cover. An open-access review of the 2019 scheme lists two types of undefined phenotype in its table.

Sources and links

• Magnusson et al. 2026 (open access) (primary)
• Verleden et al. 2019 (DOI)
• Yoshiyasu and Sato 2020, phenotype table (open access)

Related

Links from this record

• described in: Phenotyping of chronic lung allograft dysfunction in the ScanCLAD study
• defined in: Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment: A consensus report from the Pulmonary Council of the ISHLT
• summarised in: Chronic lung allograft dysfunction post-lung transplantation: The era of bronchiolitis obliterans syndrome and restrictive allograft syndrome

Linked from (derived)

• classifies: Phenotyping CLAD after single lung transplant: Limits and prognostic assessment of the 2019 ISHLT classification system
• compares: Risk assessment of chronic lung allograft dysfunction phenotypes: Validation and proposed refinement of the 2019 International Society for Heart and Lung Transplantation classification system
• discusses: Phenotyping of chronic lung allograft dysfunction in the ScanCLAD study
• defines: Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment: A consensus report from the Pulmonary Council of the ISHLT
• describes: Chronic lung allograft dysfunction post-lung transplantation: The era of bronchiolitis obliterans syndrome and restrictive allograft syndrome
• affects: Clinical CLAD phenotypes are hard to assign reproducibly

Known gaps in this record

• the two undefined sub-types are not described here (table detail not captured)