Beyond Bronchiolitis Obliterans: In-Depth Histopathologic Characterization of Bronchiolitis Obliterans Syndrome after Lung Transplantation

Summary

Explant tissue from 52 clinically defined BOS patients and 26 non-CLAD patients (1993 to 2018) was analysed for airway lesions, vasculopathy and fibrosis. Bronchiolitis obliterans lesions were present in 38 BOS patients (73 percent) and varied from concentric fibrotic to inflammatory; 10 of 14 BOS patients without them showed vanishing airways. Chronic vascular abnormalities were found in 22 (42 percent), and Ashcroft score of 5 or above fibrosis in 28 (54 percent). Non-CLAD patients had no obliterative lesions and lower fibrosis scores (p=0.0038). The authors conclude BOS explants show varied histologic findings, including vasculopathy and fibrosis. Explants represent end-stage disease.

Details

doi

10.3390/jcm11010111

pmid

35011851

authors

Vanstapel A, Verleden SE, Verbeken EK, Braubach P, Goos T, De Sadeleer L, Kaes J, Vanaudenaerde BM, Jonigk D, Ackermann M, Ceulemans LJ, Van Raemdonck DE, Neyrinck AP, Vos R, Verleden GM, Weynand B, On Behalf Of The Leuven Lung Transplant Group

journal

Journal of Clinical Medicine

year

2021

volume

11

issue

1

pages

111

Sources and links

• Publisher record via DOI (primary)
• PubMed 35011851

Related

Links from this record

• characterises: Bronchiolitis obliterans syndrome (BOS)
• authors affiliated with: KU Leuven BREATHE (Laboratory of Respiratory Diseases and Thoracic Surgery)
• coauthor: Robin Vos
• coauthor: Geert Verleden
• coauthor: Bart Vanaudenaerde

Linked from (derived)

• author: Arne Neyrinck
• author: Bart Vanaudenaerde
• author: Geert Verleden
• author: Laurens Joseph Ceulemans
• author: Robin Vos
• evidence: Clinical CLAD phenotypes are hard to assign reproducibly

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• full text not read (abstract only)
• funding statement and grant numbers