Circulating exosomes with lung self-antigens as a biomarker for chronic lung allograft dysfunction: A retrospective analysis

Summary

Exosomes are small membrane vesicles released by cells. The study isolated circulating exosomes retrospectively from plasma of lung transplant recipients at diagnosis of BOS and at 6 and 12 months before diagnosis (n = 41), and from stable time-matched controls (n = 30) at two transplant centres, and measured the self-antigens K-alpha 1 tubulin and collagen V. According to the abstract, exosomes from recipients with BOS had higher levels of these self-antigens, including 12 months before diagnosis, with 100 percent specificity and 90 percent sensitivity reported, and a validation study in two further cohorts gave similar findings. The authors conclude that such exosomes could serve as a non-invasive biomarker for recipients at risk of BOS. The findings are retrospective and have not been tested here beyond the abstract.

Details

doi

10.1016/j.healun.2020.07.001

pmid

32713614

authors

Sharma M, Gunasekaran M, Ravichandran R, Fisher CE, Limaye AP, Hu C, McDyer J, Kaza V, Bharat A, Tokman S, Omar A, Arjuna A, Walia R, Bremner RM, Smith MA, Hachem RR, Mohanakumar T

journal

The Journal of Heart and Lung Transplantation

year

2020

volume

39

issue

11

pages

1210-1219

Sources and links

• Publisher record via DOI (primary)
• PubMed 32713614

Related

Links from this record

• related to: Autoantibodies
• discusses: Bronchiolitis obliterans syndrome (BOS)

Linked from (derived)

• author affiliation matches this institution (PubMed): UPMC Lung Transplant Program
• author affiliation matches this institution (PubMed): Lung Transplant Program, Washington University in St. Louis and Barnes-Jewish Hospital

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• author affiliations
• centre or centres not stated in the abstract