Airway pepsinogen A4 identifies lung transplant recipients with microaspiration and predicts chronic lung allograft dysfunction

Summary

The authors compared expression of pepsinogens in lung tissue, measured total pepsin and pepsinogen A4 (PGA4) in large airway bronchial washings, and assessed CLAD in two independent cohorts of lung transplant recipients, with a third cohort used for antireflux surgery. According to the abstract, PGA4 was expressed in healthy human stomach but not lung; airway PGA4, but not total pepsin, was associated with aspiration; airway PGA4 was associated with increased CLAD risk in both cohorts; and antireflux surgery was associated with reduced airway PGA4. The authors propose measuring PGA4 at surveillance bronchoscopy to triage high-risk recipients for antireflux surgery. Cohort sizes are not stated in the abstract.

Details

doi

10.1016/j.healun.2024.01.002

pmid

38211836

authors

Ramendra R, Duong A, Zhang CYK, Huszti E, Zhou X, Havlin J, Ghany R, Cypel M, Yeung JC, Keshavjee S, Sage AT, Martinu T

journal

The Journal of Heart and Lung Transplantation

year

2024

volume

43

issue

6

pages

973-982

Sources and links

• Publisher record via DOI (primary)
• PubMed 38211836

Related

Links from this record

• describes: Aspiration
• studies: Gastro-oesophageal reflux, oesophageal dysmotility and aspiration
• relates to: Bronchoalveolar lavage: cell counts, microbiology and protein markers
• authors affiliated with: Toronto Lung Transplant Program (University Health Network)
• coauthor: Andrew Sage
• coauthor: Shaf Keshavjee
• coauthor: Marcelo Cypel
• coauthor: Tereza Martinu

Linked from (derived)

• author: Andrew Sage
• author: Jonathan C. Yeung
• author: Marcelo Cypel
• author: Rasheed Ghany
• author: Shaf Keshavjee
• author: Tereza Martinu

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• cohort sizes