Oesophageal stasis is a risk factor for chronic lung allograft dysfunction and allograft failure in lung transplant recipients.
Evidence level: retrospective single-centre cohort (487 recipients); abstract-only
A Toronto cohort of 487 lung transplant recipients in which oesophageal outflow obstruction and major peristalsis disorders were associated with a higher hazard of CLAD and allograft failure.
As of . Primary source: Publisher record via DOI.
Summary
According to the abstract, all recipients at the Toronto Lung Transplant Program from 2012 to 2018 with oesophageal manometry within the first 7 months after transplant were included (487 patients) and classified by the Chicago Classification v3.0. Of these, 57 (12 percent) had oesophagogastric junction outflow obstruction (OGJOO) and 47 (10 percent) had a disorder of peristalsis (8 major, 39 minor). In multivariable analysis, OGJOO was associated with an increased risk of CLAD (hazard ratio 1.71, 95 percent confidence interval 1.15 to 2.55) and of allograft failure (hazard ratio 1.69, 1.13 to 2.53), and major disorders of peristalsis with CLAD (hazard ratio 1.55, 1.01 to 2.37) and allograft failure (hazard ratio 3.33, 1.53 to 7.25). Minor disorders of peristalsis were not significantly associated. The study is retrospective and shows association. Authors include Tereza Martinu and Shaf Keshavjee.
Details
- doi
- 10.1183/23120541.00222-2023
- pmid
- 37817870
- authors
- Ramendra R, Fernández-Castillo JC, Huszti E, Ghany R, Aversa M, Havlin J, Riddell P, Chaparro CM, Singer LG, Liu L, Keshavjee S, Yeung JC, Martinu T
- journal
- ERJ Open Research
- year
- 2023
- volume
- 9
- issue
- 5
- articleNumber
- 00222-2023
- publishedOnline
- 2023-08-17
Sources and links
- Publisher record via DOI (primary)
- PubMed 37817870
Related
Links from this record
- supports: Aspiration
- coauthor: Tereza Martinu
- affiliation named in PubMed record (Toronto Lung Transplant Program): Toronto Lung Transplant Program (University Health Network)
Linked from (derived)
- supports: Gastro-oesophageal reflux, oesophageal dysmotility and aspiration
- author: Lianne Singer
- author: Shaf Keshavjee
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- full author affiliations (only the PubMed affiliation text was checked for named centres)
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.