Spectrum of chronic lung allograft pathology in a mouse minor-mismatched orthotopic lung transplant model

Summary

The authors used a mouse orthotopic left lung transplant model with a minor-antigen mismatch (B10 donors into B6 recipients) and two control combinations, and scored pathology blindly four weeks after transplant. According to the abstract, obliterative bronchiolitis was present in 66 percent of B10 to B6 grafts and 30 percent of B6 to B10 grafts, and most mice with obliterative bronchiolitis also had parenchymal fibrosis with a pleuroparenchymal fibroelastosis pattern, reminiscent of human RAS-related pathology. The authors conclude that grading of airway fibrosis, parenchymal fibrosis, acute rejection, vascular fibrosis and epithelial changes can make the model more useful for mechanistic studies. This is an animal study, and its findings may not apply to humans.

Details

doi

10.1111/ajt.15167

pmid

30378739

authors

Martinu T, Oishi H, Juvet SC, Cypel M, Liu M, Berry GJ, Hwang DM, Keshavjee S

journal

American Journal of Transplantation

year

2019

volume

19

issue

1

pages

247-258

Sources and links

• Publisher record via DOI (primary)
• PubMed 30378739

Related

Links from this record

• models features of: Restrictive allograft syndrome (RAS)
• models features of: Bronchiolitis obliterans syndrome (BOS)
• author: Tereza Martinu
• coauthor: Stephen Juvet

Linked from (derived)

• author affiliation matches this institution (PubMed): Stanford Lung Transplant Program

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• full text not read (abstract only)
• funding statement and grant numbers
• author affiliations
• centre or centres not stated in the abstract