Eosinophils in transbronchial biopsies: a predictor of chronic lung allograft dysfunction and reduced survival after lung transplantation — a retrospective single‐center cohort study.

Summary

According to the abstract, 8,887 transbronchial biopsy reports from 1,440 patients transplanted between 2001 and 2018 were reviewed for mention of eosinophils; 112 patients (7.8 percent) had eosinophils on at least one biopsy. In multivariable analysis, eosinophil detection was independently associated with an increased risk of death (hazard ratio 1.51, 95 percent confidence interval 1.24 to 1.85) and of CLAD (hazard ratio 1.35, 1.07 to 1.70). The authors suggest that reporting eosinophils in biopsy reports may be of value. The study is retrospective and single-centre. The authors include Tereza Martinu and Shaf Keshavjee.

Details

doi

10.1111/tri.13760

pmid

33025592

authors

Darley DR, Ma J, Huszti E, Fiset P, Levy L, Hwang DM, Pal P, Klement W, Zamel R, Keshavjee S, Tomlinson G, Singer LG, Tikkanen JM, Martinu T

journal

Transplant International

year

2021

volume

34

issue

1

pages

62-75

publishedOnline

2020-11-16

Sources and links

• Publisher record via DOI (primary)
• PubMed 33025592

Related

Links from this record

• coauthor: Tereza Martinu
• affiliation named in PubMed record (Toronto Lung Transplant Program): Toronto Lung Transplant Program (University Health Network)

Linked from (derived)

• supports: Transbronchial biopsy: histology and transcript-based classifiers
• author: Lianne Singer
• author: Shaf Keshavjee

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• full author affiliations (only the PubMed affiliation text was checked for named centres)