GRAfT 2.0. A Multimodal Prospective Approach to Define the Mechanisms and Clinical Features of Acute and Chronic Rejection in Lung Transplantation

Summary

The ClinicalTrials.gov entry describes an observational study with an estimated 100 participants, aged 18 to 75 years, who have progressive lung disease or have undergone, or may undergo, lung transplantation. Participants attend clinic visits every 3 to 6 months for up to 4 years. The registry lists the primary outcome as multi-omic molecular differences between participants with donor-specific antibodies who progress to antibody-mediated rejection and those who do not. No interventions are listed. No results are posted.

Details

registry

ClinicalTrials.gov

registryId

NCT07516379

registryTitle

GRAfT 2.0. A Multimodal Prospective Approach to Define the Mechanisms and Clinical Features of Acute and Chronic Rejection in Lung Transplantation

sponsor

National Heart, Lung, and Blood Institute (NHLBI)

registryStatus

recruiting

studyType

observational

enrolment

100 (estimated)

startDate

2026-05-11 (actual)

primaryCompletionDate

2032-03-27 (estimated)

condition

Lung Transplant; End Stage Lung Disease; Rejection

registryLastUpdatePosted

2026-07-22

registryRead

2026-10-10

Sources and links

• ClinicalTrials.gov NCT07516379 (primary)
• ClinicalTrials.gov API v2 record for NCT07516379

Known gaps in this record

• acronym: not shown in the registry entry
• phase (not listed for observational studies): not shown in the registry entry
• intervention (none listed in the structured fields): not shown in the registry entry
• results: none posted in the registry
• participating centres and investigators: not recorded
• link to a CLADsolve centre record: not made