Pseudomonal airway colonisation: risk factor for bronchiolitis obliterans syndrome after lung transplantation?

Summary

According to the abstract, 92 double lung recipients (26 with cystic fibrosis, 66 without) with at least two consecutive bronchoalveolar lavage or sputum cultures evaluated for pseudomonads were studied for freedom from BOS in colonised versus non-colonised patients. The abstract reports that post-operative colonisation was an independent risk factor for BOS stage 1 or higher and was associated with worse BOS-free survival in univariate analysis, especially in cystic fibrosis recipients; in multivariate analysis colonisation showed only a trend as an independent risk factor. The authors conclude that colonisation may be associated with an increased prevalence of BOS and that its pathophysiological mechanisms need further investigation. The study is retrospective. The PubMed affiliation reads Laboratory of Pneumology, Katholieke Universiteit Leuven; BREATHE is not named.

Details

doi

10.1183/09031936.00128607

pmid

18256072

authors

Vos R, Vanaudenaerde BM, Geudens N, Dupont LJ, Van Raemdonck DE, Verleden GM

journal

European Respiratory Journal

year

2008

volume

31

issue

5

pages

1037-1045

publishedOnline

2008-02-06

Sources and links

• Publisher record via DOI (primary)
• PubMed 18256072

Related

Links from this record

• discusses: Bronchiolitis obliterans syndrome (BOS)
• related to: Microbial dysbiosis

Linked from (derived)

• culture use: Bronchoalveolar lavage: cell counts, microbiology and protein markers
• supports: Airway colonisation: Pseudomonas and fungal infection

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• full author affiliations (only the PubMed affiliation text was checked for named centres)
• link to the BREATHE record not made: the affiliation text names the Laboratory of Pneumology, KU Leuven, not BREATHE