Chronic lung allograft dysfunction and restrictive allograft syndrome: are phenotypes robust and helpful?
Evidence level: narrative review; abstract-only
A short review states that the 2019 CLAD phenotypes are hard to assign from lung function alone and that chest imaging helps establish prognosis.
As of . Primary source: Publisher record via DOI.
Summary
The review notes that the 2019 consensus defined four phenotypes (BOS, RAS, mixed and undefined) and that validation in real-life cohorts has been performed after bilateral and single lung transplantation. The authors report that precise phenotyping based on pulmonary function alone can be difficult, that regular chest CT appears very helpful for prognosis, and that pulmonary function changes may not always identify the exact phenotype.
Details
- doi
- 10.1097/MOT.0000000000000962
- pmid
- 35649111
- authors
- Verleden GM, Godinas L, Vos R, Verleden SE
- journal
- Current Opinion in Organ Transplantation
- year
- 2022
- volume
- 27
- issue
- 3
- pages
- 211-216
Sources and links
- Publisher record via DOI (primary)
- PubMed 35649111
Related
Links from this record
- discusses: ISHLT 2019 CLAD states: Potential, Possible, Probable and Definite
- discusses: Restrictive allograft syndrome (RAS)
- supports: Chest CT: parenchymal patterns and density in CLAD
- authors affiliated with: KU Leuven BREATHE (Laboratory of Respiratory Diseases and Thoracic Surgery)
- coauthor: Robin Vos
- coauthor: Geert Verleden
Linked from (derived)
- author: Geert Verleden
- author: Laurent Godinas
- author: Robin Vos
- evidence: Clinical CLAD phenotypes are hard to assign reproducibly
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- full text (not read)
- funding and conflicts of interest
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.