Impact of CLAD Phenotype on Survival After Lung Retransplantation: A Multicenter Study

Summary

Patients who received a repeat lung transplant for respiratory failure due to CLAD at four transplant centres between 2003 and 2013 were analysed retrospectively. BOS and restrictive CLAD (rCLAD) were distinguished using lung function, imaging and explant histopathology. Of 143 patients, 94 (66 percent) had BOS and 49 (34 percent) had rCLAD. The abstract reports that survival after retransplantation was worse for rCLAD than for BOS (unadjusted hazard ratio 2.60, 95 percent confidence interval 1.59 to 4.24), that patients with rCLAD redeveloped CLAD earlier and were more likely to redevelop rCLAD, and that the authors recommend careful discussion of retransplantation for rCLAD, particularly when other peri-operative risk factors are present. The names of the four centres are not stated in the abstract. This summary describes the literature and is not medical advice.

Details

doi

10.1111/ajt.13281

pmid

25940517

authors

Verleden SE, Todd JL, Sato M, Palmer SM, Martinu T, Pavlisko EN, Vos R, Neyrinck A, Van Raemdonck D, Saito T, Oishi H, Keshavjee S, Greer M, Warnecke G, Gottlieb J, Haverich A

journal

American Journal of Transplantation

year

2015

volume

15

issue

8

pages

2223-2230

Sources and links

• Publisher record via DOI (primary)
• PubMed 25940517

Related

Links from this record

• compares: Bronchiolitis obliterans syndrome (BOS)
• compares: Restrictive allograft syndrome (RAS)
• coauthor: Tereza Martinu

Linked from (derived)

• described in: Retransplantation
• author affiliation matches this institution (PubMed): Duke Lung Transplant Program
• author affiliation matches this institution (PubMed): Lung transplantation, Hannover Medical School (MHH)

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• author affiliations
• centre or centres not stated in the abstract