Survival determinants in lung transplant patients with chronic allograft dysfunction
Evidence level: retrospective single-centre cohort; abstract-only
A single-centre retrospective study of survival determinants after a diagnosis of CLAD, reporting about 28 percent with a restrictive pattern.
As of . Primary source: Publisher record via DOI.
Summary
In this retrospective single-centre study, CLAD was diagnosed in 71 of 294 patients (24.2 percent), on average about 31 months after transplantation. Lung function was obstructive in 51 patients and restrictive in 20; 17 of the 20 had persistent parenchymal infiltrates on CT. The abstract reports that early development of CLAD, previous neutrophilic reversible allograft dysfunction (NRAD) and a restrictive lung function pattern (or persistent infiltrates) were associated with worse survival in multivariate analysis. The authors state that the restrictive group is compatible with the recently defined restrictive allograft syndrome phenotype. The name of the centre is not stated in the abstract.
Details
- doi
- 10.1097/tp.0b013e31822bf790
- pmid
- 21836537
- authors
- Verleden GM, Vos R, Verleden SE, De Wever W, De Vleeschauwer SI, Willems-Widyastuti A, Scheers H, Dupont LJ, Van Raemdonck DE, Vanaudenaerde BM
- journal
- Transplantation
- year
- 2011
- volume
- 92
- issue
- 6
- pages
- 703-708
Sources and links
- Publisher record via DOI (primary)
- PubMed 21836537
Related
Links from this record
- reports outcomes of: Restrictive allograft syndrome (RAS)
- reports outcomes of: Bronchiolitis obliterans syndrome (BOS)
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- author affiliations
- centre or centres not stated in the abstract
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.