Intra-subject variability in oscillometry correlates with acute rejection and CLAD post-lung transplant

Summary

Of 289 bilateral lung recipients enrolled for oscillometry before spirometry (December 2017 to March 2020), 37 developed CLAD and 29 had oscillometry at onset; they were time-matched with 129 CLAD-free recipients. The A-score of cumulative rejection was positively associated with variance in oscillometry. Higher variance in measures of ventilatory inhomogeneity (X5, AX, R5-19) was independently associated with higher CLAD risk (p below 0.05), with no association for variance in percent predicted FEV1. The authors suggest oscillometry monitoring could permit earlier identification of graft injury. The number of CLAD events is small. The journal is Frontiers in Medicine according to Crossref.

Details

doi

10.3389/fmed.2023.1158870

pmid

37305133

authors

Vasileva A, Hanafi N, Huszti E, Matelski J, Belousova N, Wu JKY, Martinu T, Ghany R, Keshavjee S, Tikkanen J, Cypel M, Yeung JC, Ryan CM, Chow CW

journal

Frontiers in Medicine

year

2023

volume

10

Sources and links

• Publisher record via DOI (primary)
• PubMed 37305133

Related

Links from this record

• compares with: Spirometry: FEV1 decline from baseline in the ISHLT 2019 CLAD definition
• relates to: Acute cellular rejection
• authors affiliated with: Toronto Lung Transplant Program (University Health Network)
• coauthor: Shaf Keshavjee
• coauthor: Marcelo Cypel
• coauthor: Tereza Martinu

Linked from (derived)

• author: Marcelo Cypel
• author: Shaf Keshavjee
• author: Tereza Martinu
• evidence: Biomarker findings are hard to validate and generalise across centres

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• external validation
• centre named in abstract