Lung microbiome quantification and bacterial density as prognostic markers in lung transplantation
Evidence level: case-control; abstract-only
A case-control study of 53 CLAD cases and 55 controls found that absolute bacterial density strengthened associations between lung microbiome type and CLAD.
As of . Primary source: Publisher record via DOI.
Summary
Lavage collected within 12 months of transplant from 53 patients who developed CLAD within 4 years and 55 who stayed CLAD-free for 5 years was used to compare the allograft microbiome. Five community state types were found, dominated by Prevotella, Streptococcus and Neisseria, Staphylococcus, Pseudomonas, or a diverse population. Bacterial density was lower in controls than cases, and normalising community-defining bacteria to total density strengthened associations with CLAD. The authors conclude absolute quantification may improve understanding of how the microbiome affects outcomes. It is a case-control association study.
Details
- doi
- 10.1016/j.healun.2025.12.017
- pmid
- 41453696
- authors
- Santilli J, Reguera-Nuñez E, Armstrong E, Wijesinha Z, Levy L, Schneeberger PHH, Ramendra R, Zhang CYK, Huszti E, Martinu T, Coburn B
- journal
- The Journal of Heart and Lung Transplantation
- year
- 2026
- volume
- 45
- issue
- 4
- pages
- 592-602
Sources and links
- Publisher record via DOI (primary)
- PubMed 41453696
Related
Links from this record
- evidence for: Microbiome-derived signals
- supports: Microbial dysbiosis
- uses: Bronchoalveolar lavage: cell counts, microbiology and protein markers
- authors affiliated with: Toronto Lung Transplant Program (University Health Network)
- coauthor: Tereza Martinu
Linked from (derived)
- author: Tereza Martinu
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- external validation
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.