Innate immune activation
Status: proposedEvidence level: proposed framework, abstract only
Innate immune activation is named in the review abstract among the pathways involved in CLAD. Proposed framework, abstract only.
As of . Primary source: Burman et al. 2026, J Heart Lung Transplant (DOI; abstract only was read).
Summary
The abstract of the review by Burman and colleagues names innate immune activation, the first-line defence of the body, among the pathways involved in CLAD. The abstract does not state the strength of the evidence for this pathway, and the full text was not read. Only the abstract of the source review was read; the full text was not read. Status: proposed framework.
Sources and links
Related
Links from this record
- described in (abstract only): CLAD: translating basic science to clinical practice
- part of proposed framework: Molecular endotypes of CLAD (proposed framework)
Linked from (derived)
- pathway named in abstract: Molecular endotypes of CLAD (proposed framework)
- supports: Airway Microbiota Determines Innate Cell Inflammatory or Tissue Remodeling Profiles in Lung Transplantation
- related to: IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants
- related to: Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression
- supports: Reprogramming alveolar macrophage responses to TGF-β reveals CCR2+ monocyte activity that promotes bronchiolitis obliterans syndrome
- related to: Shared roles of immune and stromal cells in the pathogenesis of human bronchiolitis obliterans syndrome
- supports: Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantation
- supports: Hyaluronan Contributes to Bronchiolitis Obliterans Syndrome and Stimulates Lung Allograft Rejection through Activation of Innate Immunity
- related to: Single-cell dissection of chronic lung allograft dysfunction reveals convergent and distinct fibrotic mechanisms
Known gaps in this record
- full text of the source review not read, so the evidence, citations and level of agreement for this item are missing
- funding and conflicts of interest of the source review not read
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.